Uric acid is the only important endogenous compound whose excretion is significantly increased by probenecid. As the excretion of uric acid increases, the body's pool of urate decreases, although the plasma concentration may not be greatly reduced. Tophaceous deposits of urate can be reabsorbed, with relief of arthritis and re-mineralization of bone. Therapy should not be started until weeks after an acute attack. Probenecid interferes with the renal secretion of penicillin, other beta-lactam antibiotics, and methotrexate, thereby decreasing their renal clearance, increasing their half-life, and elevating their plasma concentrations if dosage adjustments are not made.
Aspirin - antagonizes the uricosuric action of probenecid. This indirectly interferes with the effect of probenecid to block uric acid reabsorption less uric acid can be reabsorbed if there is less uric acid secreted into the urine upstream of probenecid's site of action on the URAT transporter. Aspirin also interferes with the clearance of methotrexate by the same mechanism Stewart et al, Stewart CF et al : Aspirin alters methotrexate disposition in rheumatoid arthritis patients.
Arthritis Rheum 34 12 This medicine may affect your body's response to anesthesia. Call your doctor if your gout symptoms do not improve, or if they get worse. Your doctor may prescribe an additional medicine called colchicine. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Ask a doctor or pharmacist if you feel you need to take a mild pain reliever. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. This list is not complete. Other drugs may affect probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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